American Express is accepted in Seychelles at American Express accepting merchants. Cards can be used in Mahé, Praslin and La Digue, as well as some of the outer islands at American Express accepting merchants. American Express Cards are accepted at a variety of merchants in all business sectors, including tourism establishments, health services, and souvenir shops.

The number of businesses accepting American Express across Seychelles continues to grow over time, through both point-of-sale (POS) terminals and e-commerce payment platforms.